منابع مشابه
Sexual conflict and protein polymorphism.
Sexual conflict, where male and female reproductive interests differ, is probably widespread and often mediated by male or sperm proteins and female or egg proteins that bind to each other during mating or fertilization. One potential consequence is maintenance of polymorphism in these proteins, which might result in reproductive isolation between sympatric subpopulations. I investigate the con...
متن کاملProtein Z levels, protein Z G79A polymorphism, and prothrombotic conditions.
Protein Z Levels, Protein Z G79A Polymorphism, and Prothrombotic Conditions To the Editor: We read with great interest the article on protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke published by Staton et al.1 The authors examine protein Z concentrations and 2 common polymorphisms of the protein Z gene in patients with a first-ever ischemic stroke and conclude that h...
متن کاملImplications of protein polymorphism on protein phase behaviour.
The phase behaviour of small globular proteins is often modeled by approximating them as spherical particles with fixed internal structure. However, changes in the local environment of a protein can lead to changes in its conformation rendering this approximation invalid. We present a simple two-state model in which protein conformation is not conserved and where the high-energy, non-native sta...
متن کاملReduced Polymorphism in Domains Involved in Protein-Protein Interactions
Genome sequencing of various individuals or isolates of the same species allows studying the polymorphism level of specific proteins and protein domains. Here we ask whether domains that are known to be involved in mediating protein-protein interactions show lower polymorphism than other domains. To this end we take advantage of a recent genome sequence dataset of 39 Saccahromyces cerevisiae st...
متن کاملFuzzy complexes: polymorphism and structural disorder in protein-protein interactions.
The notion that all protein functions are determined through macromolecular interactions is the driving force behind current efforts that aim to solve the structures of all cellular complexes. Recent findings, however, demonstrate a significant amount of structural disorder or polymorphism in protein complexes, a phenomenon that has been largely overlooked thus far. It is our view that such dis...
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ژورنال
عنوان ژورنال: Nature New Biology
سال: 1972
ISSN: 0090-0028,2058-1092
DOI: 10.1038/newbio237031a0